SCHEMBL8310241

SCHEMBL8310241

CC1(C)CC(=O)OC(=O)C1(C)C

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
HPGD P15428 1/20 0.32
TP53 P04637 3/20 0.32
CYP3A4 P08684 3/20 0.32
MAPK1 P28482 3/20 0.32
LMNA P02545 3/20 0.32
HIF1A Q16665 2/20 0.32
CYP1A2 P05177 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
NFKB1 P19838 1/20 0.32
THPO P40225 1/20 0.32
PPM1B O75688 1/20 0.32
PTPN1 P18031 1/20 0.32
PPP1CC P36873 1/20 0.32
TFPI2 P48307 1/20 0.32
PPP5C P53041 1/20 0.32
PPP2CA P67775 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL237697 0.74
SCHEMBL4163556 0.74 TP53 (0.34) KDM4EALDH1A1HPGDTP53CYP3A4
SCHEMBL14493842 0.73 LMNA (0.31) ALDH1A1LMNACYP2C9
SCHEMBL11584532 0.70
SCHEMBL14904470 0.68 KDM4E (0.32) KDM4EALDH1A1HPGDTP53CYP3A4
SCHEMBL5119335 0.68 TP53 (0.42) KDM4ETP53CYP3A4MAPK1LMNA
SCHEMBL16045815 0.67 LMNA (0.31) LMNACYP2C9
SCHEMBL16405076 0.67 TSHR (0.35) TSHR
SCHEMBL159517 0.67 ALDH1A1 (0.44) KDM4EALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL13495790 0.67 ALDH1A1 (0.34) KDM4EALDH1A1HPGDTP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11999908-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-06-04 US disclosed
US-11975499-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-05-07 US disclosed
US-11945181-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-04-02 US disclosed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US disclosed
CN-115605529-B Photochromic polydiorganosiloxane vinyl cross-linking agent 爱尔康公司 2024-03-26 CN disclosed
EP-4118134-B1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2024-02-28 EP disclosed
EP-4313567-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-02-07 EP disclosed
EP-4314118-A1 POLYSILOXANE VINYLIC CROSSLINKERS WITH HIGH REFRACTIVE INDEX Alcon Inc. (CH) 2024-02-07 EP disclosed
US-11886045-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-01-30 US disclosed
EP-4304843-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP disclosed
CN-108475822-B Nonaqueous electrolyte solution for secondary battery and secondary battery provided with same 斯泰拉化工公司 2022-03-11 CN disclosed
US-20210371731-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2021-12-02 US disclosed
US-20210284806-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 US disclosed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US disclosed
WO-2021181341-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO disclosed
WO-2021181307-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO disclosed
EP-0646116-B1 PROCESS AND INTERMEDIATES FOR BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS PFIZER (US) 1999-10-13 EP disclosed
US-5719286-A Process and intermediates for bis-aza-bicyclic anxiolytic agents PFIZER INC. (US) 1998-02-17 US disclosed
EP-0646116-A1 PROCESS AND INTERMEDIATES FOR BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS PFIZER INC. (US) 1995-04-05 EP disclosed
WO-1993025552-A1 PROCESS AND INTERMEDIATES FOR BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS PFIZER INC. (US) 1993-12-23 WO disclosed