Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 2/20 | 0.63 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13117246 | 1.00 | SLC5A1 (0.63) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL29179321 | 0.95 | PDE4A (0.63) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL30892448 | 0.95 | PDE4A (0.63) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL24983864 | 0.95 | PDE4A (0.63) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL30141094 | 0.95 | PDE4A (0.63) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL1727986 | 0.91 | SLC5A1 (0.72) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL1727983 | 0.91 | SLC5A1 (0.72) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL30383800 | 0.91 | SLC5A1 (0.72) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL5838566 | 0.89 | MAPT (0.70) | SLC5A1SLC5A2PDE4APDE4BPDE4C | |
| SCHEMBL5838556 | 0.89 | MAPT (0.70) | SLC5A1SLC5A2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638554-B2 | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2009-12-29 | — | — | US | disclosed |
| US-7329687-B2 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2008-02-12 | — | — | US | disclosed |
| US-20060264500-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2006-11-23 | — | — | US | disclosed |
| EP-1495014-A2 | NOVEL FLAVANOIDS AND CHALCONES AS CHEMOTHERAPEUTIC, CHEMOPREVENTIVE, AND ANTIANGIOGENIC AGENTS | Sri International (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20040029914-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL | 2004-02-12 | — | — | US | disclosed |
| US-20030229136-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL | 2003-12-11 | — | — | US | disclosed |
| WO-2003089423-A2 | NOVEL FLAVANOIDS AND CHALCONES AS CHEMOTHERAPEUTIC, CHEMOPREVENTIVE, AND ANTIANGIOGENIC AGENTS | SRI INTERNATIONAL (US) | 2003-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264500-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | FLT1, CCNE1, CCNA1 | SLC5A1 1841/4885SLC5A2 3536/4885PDE4A 2763/4885 |
| US-20040029914-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | FLT1, VEGFA, FLT4 | SLC5A1 1010/4885SLC5A2 2623/4885PDE4A 3123/4885 |
| US-20030229136-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | FLT1, VEGFA, FLT4 | SLC5A1 1118/4885SLC5A2 2651/4885PDE4A 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.