Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.77 |
| ▸ | CDK4 | P11802 | 6/20 | 0.41 |
| ▸ | CCND1 | P24385 | 4/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.40 |
| ▸ | TYK2 | P29597 | 5/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416712 | 0.91 | CDK2 (0.74) | CDK2CDK4CCND1CDK9CDK11A | |
| SCHEMBL4413597 | 0.89 | CDK2 (0.72) | CDK2CDK4CCND1JAK1TYK2 | |
| SCHEMBL4416745 | 0.87 | CDK2 (0.69) | CDK2CDK4CCND1CDK9CDK11A | |
| SCHEMBL4419524 | 0.87 | CDK2 (1.00) | CDK2CDK4CCND1CDK9CDK11A | |
| SCHEMBL4419088 | 0.83 | CDK2 (0.74) | CDK2CDK1MEN1KMT2A | |
| SCHEMBL4411192 | 0.81 | CDK2 (0.61) | CDK2CDK4CCND1JAK1TYK2 | |
| SCHEMBL6027265 | 0.78 | CDK2 (0.73) | CDK2MEN1KMT2AMAPT | |
| SCHEMBL6027091 | 0.76 | CDK2 (0.54) | CDK2CDK4CCND1CDK1CCNB1 | |
| SCHEMBL3839632 | 0.74 | CDK2 (0.52) | CDK2CDK4CCND1CDK1CCNB1 | |
| SCHEMBL4412149 | 0.72 | CDK2 (0.81) | CDK2CDK4CCND1JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689394-A4 | AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-03 | — | — | EP | disclosed |
| US-7109220-B2 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-19 | — | — | US | disclosed |
| EP-1689394-A1 | AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-08-16 | — | — | EP | disclosed |
| US-20050124610-A1 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N. V. (BE) | 2005-06-09 | — | — | US | disclosed |
| WO-2005051387-A1 | AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124610-A1 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | CDK6, CDK1, CDK3 | CDK2 4/4885CDK4 7/4885CCND1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.