Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.74 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | TYK2 | P29597 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414254 | 0.91 | CDK2 (0.77) | CDK2JAK1TYK2JAK3MAPT | |
| SCHEMBL4413597 | 0.90 | CDK2 (0.72) | CDK2JAK1TYK2JAK3RAB9A | |
| SCHEMBL4419088 | 0.87 | CDK2 (0.74) | CDK2MEN1KMT2A | |
| SCHEMBL4419524 | 0.86 | CDK2 (1.00) | CDK2JAK1TYK2JAK3CCNA2 | |
| SCHEMBL4411192 | 0.85 | CDK2 (0.61) | CDK2JAK1TYK2JAK3MAPT | |
| SCHEMBL6027265 | 0.82 | CDK2 (0.73) | CDK2MAPTMEN1KMT2A | |
| SCHEMBL18616287 | 0.79 | AURKA (0.53) | CDK2JAK1TYK2JAK3MAPT | |
| SCHEMBL6027091 | 0.77 | CDK2 (0.54) | CDK2MEN1KMT2ACDK4CCND1 | |
| SCHEMBL3839632 | 0.75 | CDK2 (0.52) | CDK2MEN1KMT2ACDK4CCND1 | |
| SCHEMBL1250645 | 0.73 | CDK2 (0.72) | CDK2MAPTCCNA2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689394-A4 | AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-03 | — | — | EP | disclosed |
| US-7109220-B2 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-19 | — | — | US | disclosed |
| EP-1689394-A1 | AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051387-A1 | AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-09 | — | — | WO | disclosed |
| US-20050124610-A1 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N. V. (BE) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124610-A1 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders | CDK6, CDK1, CDK3 | CDK2 4/4885JAK1 165/4885TYK2 371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.