Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27848505 | 0.98 | DYRK1A (0.34) | DYRK1ASMN1; SMN2HSD17B10CYP19A1ACHE | |
| SCHEMBL27865531 | 0.78 | CYP3A4 (0.40) | SMN1; SMN2HSD17B10ACHEGAAALDH1A1 | |
| SCHEMBL27974432 | 0.78 | LMNA (0.36) | HSD17B10ACHEGAAALDH1A1TP53 | |
| SCHEMBL4276128 | 0.78 | DAO (0.34) | ACHEGAAALDH1A1LMNACYP3A4 | |
| SCHEMBL27864491 | 0.77 | MAPK1 (0.38) | ACHELMNACYP3A4TNFSF11PDE3B | |
| SCHEMBL27633318 | 0.74 | HCAR2 (0.36) | SMN1; SMN2HSD17B10ACHEGAAALDH1A1 | |
| SCHEMBL27683380 | 0.72 | DYRK1A (0.34) | DYRK1AACHEGAAALDH1A1PDE3B | |
| Hydrochloric Acid SCHEMBL219321 | 0.71 | — | — | |
| SCHEMBL27906348 | 0.70 | GAA (0.55) | SMN1; SMN2GAAKMT2ATP53RAB9A | |
| SCHEMBL27801324 | 0.70 | HCAR2 (0.45) | DYRK1ASMN1; SMN2HSD17B10GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102762571-A | Heterocyclic compounds as janus kinase inhibitors | BIOCRYST PHARM INC | 2012-10-31 | — | — | CN | disclosed |
| CN-101443339-B | Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group | ASTRAZENECA AB | 2012-07-04 | — | — | CN | disclosed |
| CN-101074227-B | Phosphine acyloxy quinazoline derivatives and their medicine uses | ASTRAZENECA AB | 2010-09-29 | — | — | CN | disclosed |
| EP-1463506-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |
| CN-101448501-A | Combination therapy for the treatment of cancer | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
| CN-101448823-A | Maleate cocrystals of AZD1152 | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
| CN-100491372-C | Substituted quinazoline derivatives as inhibitors of aurora kinase | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| CN-101443339-A | Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| CN-101115738-A | Pyrazolylamino substituted quinazoles for the treatment of cancer | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | CN | disclosed |
| CN-101074227-A | Phosphine acyloxy quinazoline derivatives and their medicine using | ASTRAZENECA AB (SE) | 2007-11-21 | — | — | CN | disclosed |
| CN-100349906-C | Phosphonoxyquinazoline derivatives and pharmaceutical use thereof | ASTRAZENECA AB (SE) | 2007-11-21 | — | — | CN | disclosed |
| CN-1764668-A | Phosphonoxyquinazoline derivatives and pharmaceutical use thereof | ASTRAZENECA AB (SE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1620296-A | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2005-05-25 | — | — | CN | disclosed |
| EP-1463506-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | Astrazeneca AB (SE) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003055491-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | WO | disclosed |