Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | FOS | P01100 | 2/20 | 0.41 |
| ▸ | JUN | P05412 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733621 | 0.81 | CYP1A2 (0.47) | MEN1KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL15215750 | 0.80 | KMT2A (0.52) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4376723 | 0.78 | KDM4E (0.49) | MEN1KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL2845477 | 0.78 | MEN1 (0.50) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL15015768 | 0.75 | MEN1 (0.51) | MEN1KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL4415502 | 0.74 | KDM4E (0.61) | MEN1KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL25238639 | 0.73 | KDM4E (0.50) | MEN1KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL29109948 | 0.72 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23361072 | 0.72 | KDM4E (0.49) | MEN1KMT2AKDM4ENPSR1HPGD | |
| SCHEMBL11013234 | 0.70 | ALDH1A1 (0.50) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | disclosed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | disclosed |
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |