Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 16/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412907 | 0.78 | PLA2G7 (0.49) | PLA2G7DAO | |
| SCHEMBL4423080 | 0.77 | PLA2G7 (0.72) | PLA2G7 | |
| SCHEMBL4414104 | 0.75 | PLA2G7 (0.71) | PLA2G7DAO | |
| SCHEMBL4415602 | 0.74 | PLA2G7 (0.56) | PLA2G7DAO | |
| SCHEMBL7585604 | 0.67 | PLA2G7 (0.78) | PLA2G7DAO | |
| SCHEMBL8138900 | 0.65 | SMN1; SMN2 (0.49) | PLA2G7KMT2ADAOMEN1 | |
| SCHEMBL7007401 | 0.64 | PLA2G7 (1.00) | PLA2G7DAO | |
| SCHEMBL11467052 | 0.64 | DAO (0.67) | PLA2G7DAO | |
| SCHEMBL7007074 | 0.64 | PLA2G7 (0.87) | PLA2G7DAO | |
| SCHEMBL7004566 | 0.63 | PLA2G7 (0.67) | PLA2G7DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |