⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203814 | 1.00 | — | — | |
| SCHEMBL6731816 | 0.97 | CA3 (0.46) | — | |
| Methyl Alcohol SCHEMBL27969182 | 0.92 | CA3 (0.48) | — | |
| Methylamine SCHEMBL27969203 | 0.92 | CA3 (0.42) | — | |
| SCHEMBL384681 | 0.86 | PSEN1 (0.40) | — | |
| Tetrahydrofuran SCHEMBL28119237 | 0.82 | CA3 (0.35) | — | |
| SCHEMBL18782552 | 0.79 | MAOB (0.39) | — | |
| SCHEMBL14413 | 0.79 | — | — | |
| SCHEMBL30411804 | 0.79 | — | — | |
| SCHEMBL29350499 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 983 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115872905-B | Preparation method of larotinib intermediate | 凯特立斯（深圳）科技有限公司 | 2024-08-09 | — | — | CN | claimed |
| CN-111793016-B | Preparation method of larotinib intermediate and intermediate compound | 钟桂发 | 2024-03-26 | — | — | CN | claimed |
| CN-114507172-B | Synthesis method of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 四川依维欣医药科技有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-117326927-A | Preparation method of 2,5-bis (2, 2-trifluoroethoxy) benzoic acid | 清源创新实验室 | 2024-01-02 | — | — | CN | claimed |
| CN-115872905-A | Preparation method of larotinib intermediate | 凯特立斯（深圳）科技有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-114507172-A | Synthesis method of (R) -2- (2, 5-difluorophenyl) pyrrolidine | 四川恒康科技发展有限公司 | 2022-05-17 | — | — | CN | claimed |
| CN-108218754-B | Preparation method of 2- (2,5-difluorophenyl) pyrrolidine | 广东赛烽医药科技有限公司 | 2021-05-07 | — | — | CN | claimed |
| CN-110981779-B | Synthesis method of R-2- (2, 5-difluorophenyl) pyrrolidine | 武汉理工大学 | 2021-02-26 | — | — | CN | claimed |
| CN-112010901-A | (2, 5-difluorophenyl) diphenyl phosphine oxide and preparation method thereof | 上海应用技术大学 | 2020-12-01 | — | — | CN | claimed |
| CN-111793016-A | Preparation method of larotinib intermediate and intermediate compound | 钟桂发 | 2020-10-20 | — | — | CN | claimed |
| US-20140120626-A1 | METHOD OF MARKING HYDROCARBON LIQUIDS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2014-05-01 | — | — | US | claimed |
| EP-2707465-A1 | METHOD OF MARKING HYDROCARBON LIQUIDS | Johnson Matthey Public Limited Company (GB) | 2014-03-19 | — | — | EP | claimed |
| WO-2012153132-A1 | METHOD OF MARKING HYDROCARBON LIQUIDS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2012-11-15 | — | — | WO | claimed |
| EP-1362860-B1 | Method for producing tetrakis (fluoraryl)borate magnesium compound | NIPPON CATALYTIC CHEM IND (JP) | 2010-09-15 | — | — | EP | claimed |
| US-7205441-B2 | Method for producing tetrakis (fluoroaryl) borate-magnesium compound | NIPPON SHOKUBAI CO., LTD. (JP) | 2007-04-17 | — | — | US | claimed |
| US-20030216598-A1 | Method for producing tetrakis ( fluoroaryl) borate-magnesium compound | NIPPON SHOKUBAI CO., LTD. (JP) | 2003-11-20 | — | — | US | claimed |
| EP-1362860-A1 | Method for producing tetrakis (fluoroaryl) borate magnesium compound | Nippon Shokubai Co., Ltd. (JP) | 2003-11-19 | — | — | EP | claimed |
| EP-0667328-B1 | Process for the preparation of aromatic fluoro compounds | CLARIANT GMBH (DE) | 1998-09-16 | — | — | EP | claimed |
| US-5498807-A | Process for the preparation of aromatic fluoro compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-03-12 | — | — | US | claimed |
| EP-0667328-A1 | Process for the preparation of aromatic fluoro compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-16 | — | — | EP | claimed |