Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL27776413 | 0.99 | DRD2 (0.39) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL4171897 | 0.83 | GRIN1 (0.37) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL4171900 | 0.83 | GRIN1 (0.37) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL4170854 | 0.83 | GRIN1 (0.37) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL4170861 | 0.83 | GRIN1 (0.37) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL27776435 | 0.82 | MAOB (0.38) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL4176470 | 0.81 | HMGCR (0.37) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL4176473 | 0.81 | HMGCR (0.37) | MAOBMAOAGRIN1GRIN2B | |
| SCHEMBL4179717 | 0.74 | TDP1 (0.46) | DRD2DRD3 | |
| SCHEMBL4179714 | 0.74 | TDP1 (0.46) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | claimed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | claimed |