Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 2/20 | 0.42 |
| ▸ | PON1 | P27169 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988007 | 0.97 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL4417695 | 0.95 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Iodide SCHEMBL4414352 | 0.95 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL6403529 | 0.82 | — | — | |
| Bromide SCHEMBL193043 | 0.82 | — | — | |
| SCHEMBL15136817 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Bromide SCHEMBL531200 | 0.80 | — | — | |
| Bromide SCHEMBL14765117 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Water SCHEMBL4948875 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Bromide SCHEMBL29479434 | 0.80 | SMN1; SMN2 (0.81) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310790-B1 | METHOD OF TARGETING MISMATCHED DNA USING PT(II) D8 SQUARE PLANAR METAL COMPLEXES | UNIV HONG KONG (CN) | 2021-12-01 | — | — | EP | disclosed |
| US-10378046-B2 | Method of targeting mismatched DNA using d8 square planar metal complexes | THE UNIVERSITY OF HONG KONG (CN) | 2019-08-13 | — | — | US | disclosed |
| US-20160369354-A1 | METHOD OF TARGETING MISMATCHED DNA USING d8 SQUARE PLANAR METAL COMPLEXES | THE UNIVERSITY OF HONG KONG (CN) | 2016-12-22 | — | — | US | disclosed |
| US-8940904-B2 | Use of transition metal-carbene complexes which do not comprise any cyclometallation via non-carbenes in OLEDs | BASF SE (DE) | 2015-01-27 | — | — | US | disclosed |
| US-8247574-B2 | Use of PT -and PD-BIS- and tetra-carbon complexes with bridged carbon ligands in OLEDs | BASF SE (DE) | 2012-08-21 | — | — | US | disclosed |
| US-20090326237-A1 | USE OF PT-AND PD-BIS-AND TETRA-CARBON COMPLEXES WITH BRIDGED CARBON LIGANDS IN OLEDS | BASF SE (DE) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326237-A1 | USE OF PT-AND PD-BIS-AND TETRA-CARBON COMPLEXES WITH BRIDGED CARBON LIGANDS IN OLEDS | PDCD1, PDCD1LG2, CD274 | SMN1; SMN2 4711/4885MEN1 3251/4885APAF1 3107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.