Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.40 |
| ▸ | BAD | Q92934 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414924 | 0.95 | PTGDR2 (0.52) | PTGDR2MCL1BADSMN1; SMN2KMT2A | |
| SCHEMBL4419630 | 0.86 | PTGDR2 (0.51) | PTGDR2MCL1ALDH1A1PPARGPPARA | |
| SCHEMBL3168073 | 0.84 | PTGDR2 (0.52) | PTGDR2MCL1BADPPARGPPARA | |
| SCHEMBL3174447 | 0.82 | PTGDR2 (0.51) | PTGDR2MCL1BADBCL2BCL2L1 | |
| SCHEMBL4415546 | 0.82 | PTGDR2 (0.42) | PTGDR2KMT2AALDH1A1 | |
| SCHEMBL4413606 | 0.82 | PTGDR2 (0.43) | PTGDR2 | |
| SCHEMBL12678715 | 0.81 | PTGDR2 (0.45) | PTGDR2MCL1BADBCL2PPARG | |
| SCHEMBL4418272 | 0.79 | PTGDR2 (0.51) | PTGDR2MCL1 | |
| SCHEMBL3168468 | 0.79 | PTGDR2 (0.57) | PTGDR2MCL1PPARGPPARA | |
| SCHEMBL12678737 | 0.77 | PTGDR2 (0.50) | PTGDR2KMT2AALDH1A1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |