Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419630 | 0.90 | PTGDR2 (0.51) | PTGDR2MCL1ADRA1DADRA1ATP53 | |
| SCHEMBL3169190 | 0.83 | PTGDR2 (0.51) | PTGDR2MCL1ADRA1DKDM4EHPGD | |
| SCHEMBL3179431 | 0.82 | PTGDR2 (0.52) | PTGDR2MCL1ADRA1DADRA1ACDC25A | |
| SCHEMBL12678721 | 0.80 | PTGDR2 (0.49) | PTGDR2MCL1MAPT | |
| SCHEMBL3169645 | 0.80 | PTGDR2 (0.55) | PTGDR2MCL1KDM4EHPGDHSD17B10 | |
| SCHEMBL4416672 | 0.79 | PTGDR2 (0.47) | PTGDR2MCL1 | |
| SCHEMBL4415546 | 0.79 | PTGDR2 (0.42) | PTGDR2TP53MAPT | |
| SCHEMBL4413606 | 0.77 | PTGDR2 (0.43) | PTGDR2 | |
| SCHEMBL17943478 | 0.77 | PTGDR2 (0.46) | PTGDR2MCL1ADRA1DHPGDADRA1A | |
| SCHEMBL4414924 | 0.76 | PTGDR2 (0.52) | PTGDR2MCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |