Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.70 |
| ▸ | THRB | P10828 | 12/20 | 0.70 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.70 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.58 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | ASPH | Q12797 | 1/20 | 0.58 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410710 | 0.89 | THRA (0.71) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL5315453 | 0.84 | EGLN1 (0.61) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4757085 | 0.83 | EGLN1 (0.61) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL522940 | 0.83 | THRA (1.00) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL523521 | 0.83 | THRA (0.91) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4408333 | 0.82 | EGLN1 (0.55) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4408962 | 0.82 | EGLN1 (0.57) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4409796 | 0.81 | EGLN1 (0.64) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4413599 | 0.81 | EGLN1 (0.58) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL27434200 | 0.81 | THRA (0.96) | THRATHRBEGLN1BBOX1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009002533-A1 | INFLAMMATORY BOWEL DISEASE THERAPIES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |