Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415286 | 0.86 | ABL1 (0.42) | ABL1CHRM5KCNH2SCN10A | |
| SCHEMBL9061989 | 0.84 | CHRM5 (0.46) | ABL1CHRM5SCN5ATEKCA12 | |
| SCHEMBL17185816 | 0.83 | SCN10A (0.41) | ABL1CHRM5SCN5ATEKCA12 | |
| SCHEMBL9061667 | 0.81 | CHRM5 (0.44) | CHRM5SCN5ATEKCA12CA9 | |
| SCHEMBL17185813 | 0.81 | SCN10A (0.48) | CHRM5SCN5ATEKCA12CA9 | |
| SCHEMBL4419569 | 0.80 | SCN10A (0.44) | CHRM5SCN5ATEKCA12CA9 | |
| SCHEMBL9061960 | 0.79 | CHRM5 (0.42) | CHRM5SCN5ACA12CA9KCNH2 | |
| SCHEMBL4415453 | 0.78 | KIF11 (0.47) | CA12CA9PIK3CAPI4KAPI4KB | |
| SCHEMBL509200 | 0.78 | PIK3CA (0.41) | ABL1KCNH2PIK3CAPI4KAPI4KB | |
| SCHEMBL9061779 | 0.78 | SUCNR1 (0.43) | CHRM5SCN5ACA12CA9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |