Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | PPIB | P23284 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424502 | 0.87 | NPSR1 (0.43) | MTNR1BGRIN2CKMT2AMEN1LMNA | |
| SCHEMBL4423047 | 0.85 | GRIN2C (0.51) | MTNR1BGRIN2CKMT2AMEN1LMNA | |
| SCHEMBL4418256 | 0.84 | KMT2A (0.52) | GRIN2CKMT2AMEN1LMNANPSR1 | |
| SCHEMBL4416192 | 0.84 | GRIN2C (0.47) | MTNR1BGRIN2CKMT2AMEN1LMNA | |
| SCHEMBL4413447 | 0.84 | KMT2A (0.55) | GRIN2CKMT2AMEN1LMNANPSR1 | |
| SCHEMBL4417027 | 0.84 | MTNR1B (0.47) | MTNR1BGRIN2CKMT2AMEN1LMNA | |
| SCHEMBL4418264 | 0.84 | MTNR1B (0.52) | MTNR1BGRIN2CKMT2AMEN1LMNA | |
| SCHEMBL6509279 | 0.82 | GRIN2C (0.52) | MTNR1BGRIN2CKMT2AMEN1LMNA | |
| SCHEMBL4416759 | 0.81 | GRIN2C (0.53) | GRIN2CKMT2AMEN1LMNANPSR1 | |
| SCHEMBL4414983 | 0.81 | GRIN2C (0.43) | MTNR1BGRIN2CKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663983-B1 | N-SUBSTITUTED, 6,8-DIALKOXY-1,2,3,4-TETRAHYDRO-1H-ISOQUINOLINE AS POTASSIUM CHANNELS MODULATORS | 4SC AG (DE) | 2009-01-21 | — | — | EP | disclosed |