Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 4/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416279 | 0.88 | PPARA (0.45) | PPARAHTR5ACD274PIM1AURKA | |
| SCHEMBL5867379 | 0.84 | SCN8A (0.47) | HTR5ABRAFSCN8AMAOBCACNA1B | |
| SCHEMBL16269146 | 0.82 | SCN8A (0.50) | SCN8ACACNA1BHDAC1 | |
| SCHEMBL4717378 | 0.80 | PPARA (0.53) | PPARAPIM1AURKAABL1NTRK1 | |
| SCHEMBL24408828 | 0.77 | GCK (0.43) | PPARACD274PIM1AURKAABL1 | |
| SCHEMBL4423057 | 0.76 | SCN8A (0.51) | HTR5ASCN9ASCN8AMAOBCACNA1B | |
| SCHEMBL2056329 | 0.75 | RAB9A (0.56) | PPARAPIM1AURKAABL1NTRK1 | |
| SCHEMBL5867395 | 0.74 | KDM1A (0.43) | PPARAPIM1CYP11B1CYP11B2KDM1A | |
| SCHEMBL20781811 | 0.73 | CYP11B1 (0.50) | PPARAPIM1AURKAABL1NTRK1 | |
| SCHEMBL9351438 | 0.73 | SMN1; SMN2 (0.58) | PPARACYP11B1CYP11B2KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |