Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.44 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 4/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418637 | 1.00 | MAOB (0.44) | MAOBGPR34PARP10MAOAMME | |
| SCHEMBL4415949 | 0.88 | MAOB (0.50) | MAOBGPR34PARP10MAOASCN9A | |
| SCHEMBL4415945 | 0.88 | MAOB (0.50) | MAOBGPR34PARP10MAOASCN9A | |
| SCHEMBL4419591 | 0.88 | MAOB (0.50) | MAOBGPR34PARP10MAOASCN9A | |
| SCHEMBL4430112 | 0.87 | HTT (0.45) | MAOBGPR34PARP10MAOASCN9A | |
| SCHEMBL4430114 | 0.87 | HTT (0.45) | MAOBGPR34PARP10MAOASCN9A | |
| SCHEMBL27540241 | 0.80 | EPHX2 (0.46) | MAOBPARP10MAOA | |
| SCHEMBL4420232 | 0.80 | MAOB (0.51) | MAOBPARP10MAOA | |
| SCHEMBL4429665 | 0.78 | MAOB (0.44) | MAOBGPR34PARP10MAOASCN9A | |
| SCHEMBL4415984 | 0.78 | MAOB (0.44) | MAOBGPR34PARP10MAOASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501804-B1 | ISOQUINOLINE DERIVATIVES MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | disclosed |
| CN-1310890-C | Isoquinoline derivatives | HOFFMANN LA ROCHE (CH) | 2007-04-18 | — | — | CN | disclosed |
| CN-1649844-A | Isoquinoline derivatives | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |
| US-6818774-B2 | 2-(S)-(6-(4-FLUORO-BENZYLOXY)-3-OXO-3,4-DIHYDRO-1H-ISOQUINOLIN -2-YL)- PROPIONAMIDE FOR EXAMPLE; ALZHEIMER'S DISEASE OR SENILE DEMENTIA | HOFFMAN-LA ROCHE INC. | 2004-11-16 | — | — | US | disclosed |
| US-20030225122-A1 | 2-(S)-(6-(4-fluoro-benzyloxy)-3-oxo-3,4-dihydro-1H-isoquinolin -2-yl)- propionamide for example; Alzheimer's disease or senile dementia | HOFFMANN-LA ROCHE INC. | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225122-A1 | 2-(S)-(6-(4-fluoro-benzyloxy)-3-oxo-3,4-dihydro-1H-isoquinolin -2-yl)- propionamide for example; Alzheimer's disease or senile dementia | MAOB, MAOA, BACE2 | MAOB 1/4885GPR34 1705/4885PARP10 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.