Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 17/20 | 0.70 |
| ▸ | LONP1 | P36776 | 11/20 | 0.70 |
| ▸ | PSMB8 | P28062 | 10/20 | 0.70 |
| ▸ | PSMB9 | P28065 | 10/20 | 0.70 |
| ▸ | PSMB6 | P28072 | 10/20 | 0.70 |
| ▸ | PSMB10 | P40306 | 10/20 | 0.70 |
| ▸ | PSMB11 | A5LHX3 | 9/20 | 0.70 |
| ▸ | PSMA7 | O14818 | 9/20 | 0.70 |
| ▸ | PSMB1 | P20618 | 9/20 | 0.70 |
| ▸ | PSMA1 | P25786 | 9/20 | 0.70 |
| ▸ | PSMA2 | P25787 | 9/20 | 0.70 |
| ▸ | PSMA3 | P25788 | 9/20 | 0.70 |
| ▸ | PSMA4 | P25789 | 9/20 | 0.70 |
| ▸ | PSMA5 | P28066 | 9/20 | 0.70 |
| ▸ | PSMB4 | P28070 | 9/20 | 0.70 |
| ▸ | PSMB3 | P49720 | 9/20 | 0.70 |
| ▸ | PSMB2 | P49721 | 9/20 | 0.70 |
| ▸ | PSMA6 | P60900 | 9/20 | 0.70 |
| ▸ | PSMA8 | Q8TAA3 | 9/20 | 0.70 |
| ▸ | PSMB7 | Q99436 | 9/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071801 | 1.00 | PSMB5 (0.70) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL17021218 | 1.00 | PSMB5 (0.70) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL10072156 | 1.00 | PSMB5 (0.70) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL24836934 | 0.96 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL1688079 | 0.96 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL1688078 | 0.95 | PSMB5 (0.67) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL25598877 | 0.95 | PSMB5 (0.64) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL10043059 | 0.94 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL8091955 | 0.93 | PSMB5 (0.62) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL25134755 | 0.92 | PSMB5 (0.61) | PSMB5LONP1PSMB8PSMB9PSMB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318419-B2 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2024-10-30 | — | — | EP | disclosed |
| US-11752164-B2 | Bortezomib compositions | MAIA Pharmaceuticals, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11752164-B2 | Bortezomib compositions | MAIA Pharmaceuticals, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20230265111-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-08-24 | — | — | US | disclosed |
| US-20230218647-A1 | BORTEZOMIB COMPOSITIONS | MAIA Pharmaceuticals, Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230218647-A1 | BORTEZOMIB COMPOSITIONS | MAIA Pharmaceuticals, Inc. | 2023-07-13 | — | — | US | disclosed |
| US-11679119-B2 | Bortezomib compositions | MAIA Pharmaceuticals, Inc. (US) | 2023-06-20 | — | — | US | disclosed |
| US-11679119-B2 | Bortezomib compositions | MAIA Pharmaceuticals, Inc. (US) | 2023-06-20 | — | — | US | disclosed |
| US-11672813-B2 | Bortezomib compositions | MAIA Pharmaceuticals, Inc. (US) | 2023-06-13 | — | — | US | disclosed |
| US-11672813-B2 | Bortezomib compositions | MAIA Pharmaceuticals, Inc. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20140349966-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARM INC (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140343314-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-11-20 | — | — | US | disclosed |
| US-8859504-B2 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2733147-A1 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-05-21 | — | — | EP | disclosed |
| EP-2730581-A1 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-05-14 | — | — | EP | disclosed |
| EP-2730579-A1 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-05-14 | — | — | EP | disclosed |
| EP-2730580-A1 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-05-14 | — | — | EP | disclosed |
| US-20140018301-A9 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| US-20130165390-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20090325903-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018301-A9 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885LONP1 1113/4885PSMB8 29/4885 |
| US-11679119-B2 | Bortezomib compositions | BAG6, PSMC5, PSMG3 | PSMB5 21/4885LONP1 1617/4885PSMB8 8/4885 |
| US-20090325903-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885LONP1 1113/4885PSMB8 29/4885 |
| US-20140349966-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885LONP1 1113/4885PSMB8 29/4885 |
| US-11752164-B2 | Bortezomib compositions | BAG6, PSMC5, PSMG3 | PSMB5 21/4885LONP1 1617/4885PSMB8 8/4885 |
| US-20230265111-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885LONP1 1113/4885PSMB8 29/4885 |
| US-20140343314-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885LONP1 1113/4885PSMB8 29/4885 |
| US-11672813-B2 | Bortezomib compositions | BAG6, PSMC5, PSMG3 | PSMB5 21/4885LONP1 1617/4885PSMB8 8/4885 |
| US-20230218647-A1 | BORTEZOMIB COMPOSITIONS | BAG6, PSMC5, PSMG3 | PSMB5 21/4885LONP1 1617/4885PSMB8 8/4885 |
| US-20130165390-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885LONP1 1113/4885PSMB8 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.