Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.53 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.53 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 4/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755920 | 0.89 | EGLN1 (0.51) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL5027666 | 0.83 | EGLN1 (0.68) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL523005 | 0.83 | EGLN1 (0.67) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL4418059 | 0.81 | EGLN1 (0.57) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL523982 | 0.75 | EGLN1 (0.55) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL2537378 | 0.74 | EGLN1 (0.68) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL522443 | 0.74 | EGLN1 (0.64) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL30274402 | 0.74 | EGLN1 (0.68) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL4973457 | 0.72 | EGLN1 (0.58) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL4411746 | 0.71 | EGLN1 (0.61) | EGLN1FTOBBOX1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| EP-1991269-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF STROKE | FIBROGEN, INC. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |
| WO-2007097929-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF STROKE | FIBROGEN, INC. (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007047194-A2 | METHODS FOR TREATING MITF-RELATED DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |