Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.57 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 2/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.42 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027666 | 0.84 | EGLN1 (0.68) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL522656 | 0.84 | EGLN1 (0.71) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL4757084 | 0.82 | EGLN1 (0.61) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL4419152 | 0.81 | EGLN1 (0.53) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL4755920 | 0.79 | EGLN1 (0.51) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL523235 | 0.79 | EGLN1 (0.70) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL5325511 | 0.75 | EGLN1 (0.61) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL5315453 | 0.75 | EGLN1 (0.61) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL522478 | 0.74 | EGLN1 (0.56) | EGLN1FTOBBOX1KDM5BKDM2A | |
| SCHEMBL4757876 | 0.74 | EGLN1 (0.59) | EGLN1FTOBBOX1KDM5BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009002533-A1 | INFLAMMATORY BOWEL DISEASE THERAPIES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |