Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413770 | 0.89 | TLR8 (0.49) | ALDH1A1CDK5CDK5R1 | |
| SCHEMBL4428304 | 0.89 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGD | |
| SCHEMBL4320875 | 0.85 | ALDH1A1 (0.64) | ALDH1A1CDK5CDK5R1KDM4EHSD17B10 | |
| SCHEMBL4426358 | 0.85 | ALDH1A1 (0.64) | ALDH1A1CDK5CDK5R1 | |
| SCHEMBL4422045 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL4315562 | 0.83 | ALDH1A1 (0.60) | ALDH1A1CDK5CDK5R1KDM4EHSD17B10 | |
| SCHEMBL4425143 | 0.83 | ALDH1A1 (0.62) | ALDH1A1CDK5CDK5R1KDM4EHPGD | |
| SCHEMBL4426557 | 0.83 | ALDH1A1 (0.62) | ALDH1A1CDK5CDK5R1 | |
| SCHEMBL4423747 | 0.82 | ALDH1A1 (0.61) | ALDH1A1CDK5CDK5R1 | |
| SCHEMBL4417512 | 0.81 | ALDH1A1 (0.60) | ALDH1A1CDK5CDK5R1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | ALDH1A1 3104/4885CDK5 288/4885CDK5R1 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.