Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.58 |
| ▸ | RAF1 | P04049 | 6/20 | 0.54 |
| ▸ | BRAF | P15056 | 6/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551704 | 0.90 | MAPK14 (0.57) | MAPK14RAF1BRAF | |
| SCHEMBL5593544 | 0.89 | RAF1 (0.59) | MAPK14RAF1BRAF | |
| SCHEMBL4410023 | 0.88 | RAF1 (0.55) | MAPK14RAF1BRAF | |
| SCHEMBL4565439 | 0.87 | RAF1 (0.56) | MAPK14RAF1BRAF | |
| SCHEMBL4552283 | 0.86 | RAF1 (0.56) | MAPK14RAF1BRAF | |
| SCHEMBL4565118 | 0.86 | RAF1 (0.56) | MAPK14RAF1BRAF | |
| SCHEMBL5593026 | 0.86 | RAF1 (0.61) | MAPK14RAF1BRAF | |
| SCHEMBL4541475 | 0.86 | RAF1 (0.56) | MAPK14RAF1BRAF | |
| SCHEMBL5603999 | 0.85 | MAPK14 (0.53) | MAPK14RAF1BRAFMAPK13MAPK12 | |
| SCHEMBL4551205 | 0.85 | RAF1 (0.62) | MAPK14RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |