SCHEMBL442000

SCHEMBL442000

C[Si](C)(C)C#CC1(O)COC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15534022 0.82
SCHEMBL23067807 0.82
SCHEMBL11971122 0.79
SCHEMBL129130 0.75 ALDH1A1 (0.39)
SCHEMBL130330 0.75 ALDH1A1 (0.33)
SCHEMBL25045767 0.75
SCHEMBL17621626 0.74
SCHEMBL24814669 0.73
SCHEMBL16569757 0.73
SCHEMBL16714 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743447-A1 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND METABOLIC DISEASES Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2026-05-20 EP disclosed
EP-4743178-A1 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND METABOLIC DISEASES Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2026-05-20 EP disclosed
WO-2025016909-A1 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND METABOLIC DISEASES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-01-23 WO disclosed
WO-2025016906-A1 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND METABOLIC DISEASES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-01-23 WO disclosed
CN-118852154-A Carboxamide substituted hetero tricyclic derivative, preparation method and application thereof 深圳微芯生物科技股份有限公司 2024-10-29 CN disclosed
EP-3186239-B1 ANTIRETROVIRAL AGENTS GILEAD SCIENCES INC (US) 2018-10-10 EP disclosed
US-9873680-B2 Therapeutic compounds GILEAD SCIENCES, INC. (US) 2018-01-23 US disclosed
US-9873680-B2 Therapeutic compounds GILEAD SCIENCES, INC. (US) 2018-01-23 US disclosed
EP-3186239-A1 ANTIRETROVIRAL AGENTS Gilead Sciences, Inc. (US) 2017-07-05 EP disclosed
WO-2016033243-A9 ANTIRETROVIRAL AGENTS GILEAD SCIENCES, INC. (US) 2016-05-19 WO disclosed
WO-2016033243-A9 ANTIRETROVIRAL AGENTS GILEAD SCIENCES, INC. (US) 2016-05-19 WO disclosed
US-20160083368-A1 THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2016-03-24 US disclosed
US-20160083368-A1 THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2016-03-24 US disclosed
WO-2016033243-A1 ANTIRETROVIRAL AGENTS GILEAD SCIENCES, INC. (US) 2016-03-03 WO disclosed
US-9212175-B2 Pharmaceutical hypocholesterolemic compositions LIPIDEON BIOTECHNOLOGY AG (CH) 2015-12-15 US disclosed
US-9212175-B2 Pharmaceutical hypocholesterolemic compositions LIPIDEON BIOTECHNOLOGY AG (CH) 2015-12-15 US disclosed
US-20150175530-A1 ANTIBACTERIAL AGENTS ACHAOGEN, INC. 2015-06-25 US disclosed
US-20150175530-A1 ANTIBACTERIAL AGENTS ACHAOGEN, INC. 2015-06-25 US disclosed
US-20150175530-A1 ANTIBACTERIAL AGENTS ACHAOGEN, INC. 2015-06-25 US disclosed
US-20120065168-A1 Pharmaceutical Hypocholesterolemic Compositions LIPIDEON BIOTECHNOLOGY AG (CH) 2012-03-15 US disclosed