Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 8/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549909 | 0.81 | GRM2 (0.49) | P2RX7KDM1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4422062 | 0.80 | SLC6A2 (0.45) | P2RX7KMOAHRNPC1RAB9A | |
| SCHEMBL8382053 | 0.77 | CYP11B1 (0.57) | P2RX7KMOKDM1ANPC1RAB9A | |
| SCHEMBL17055810 | 0.77 | CYP11B1 (0.44) | P2RX7KDM1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4423076 | 0.77 | KMO (0.56) | KMOAHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8024771 | 0.76 | AHR (0.61) | KMOAHRS1PR1 | |
| SCHEMBL29258492 | 0.75 | KDM1A (0.43) | KDM1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12002675 | 0.74 | NPC1 (0.61) | KDM1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2216313 | 0.74 | FYN (0.56) | KDM1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12970151 | 0.74 | KDM1A (0.53) | KDM1ANPC1RAB9ASMN1; SMN2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |