Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846285 | 0.82 | KLKB1 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15436874 | 0.79 | HPGD (0.41) | ALDH1A1KDM4EFEN1ALOX5APHPGD | |
| SCHEMBL30496159 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDCYP1A2CYP2D6 | |
| SCHEMBL10527716 | 0.76 | HPGD (0.41) | ALDH1A1KDM4EFEN1ALOX5APHPGD | |
| SCHEMBL3791629 | 0.76 | HPGD (0.51) | ALDH1A1KDM4EHPGDCYP1A2CYP2D6 | |
| SCHEMBL25198363 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDCYP1A2CYP2D6 | |
| SCHEMBL30496171 | 0.76 | HPGD (0.41) | ALDH1A1KDM4EHPGDCYP1A2CYP2D6 | |
| SCHEMBL1161590 | 0.76 | HPGD (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL14510730 | 0.76 | HPGD (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL497229 | 0.76 | HPGD (0.41) | ALDH1A1KDM4EHPGDCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040698-A2 | OXIME COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008008398-A2 | OXIME COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2008-01-17 | — | — | WO | disclosed |