Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.65 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562632 | 0.96 | CCR2 (0.67) | CCR2KCNH2SLC6A7SYK | |
| SCHEMBL4422389 | 0.91 | CCR2 (0.65) | CCR2KCNH2ACACB | |
| SCHEMBL4416071 | 0.86 | CCR2 (0.53) | CCR2KCNH2 | |
| SCHEMBL4414418 | 0.85 | CCR2 (0.65) | CCR2KCNH2SYK | |
| SCHEMBL1381009 | 0.84 | CCR2 (0.67) | CCR2KCNH2SYK | |
| SCHEMBL1377287 | 0.83 | CCR2 (0.62) | CCR2KCNH2SYK | |
| SCHEMBL1378358 | 0.82 | CCR2 (0.67) | CCR2KCNH2SYK | |
| SCHEMBL4337987 | 0.82 | CCR2 (0.94) | CCR2KCNH2 | |
| SCHEMBL4420733 | 0.82 | CCR2 (0.94) | CCR2KCNH2 | |
| SCHEMBL4425771 | 0.81 | CCR2 (0.62) | CCR2KCNH2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696919-A4 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1696919-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | Incyte Corporation (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005060665-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |