Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730528 | 0.89 | ACACB (0.52) | ACACBACACAKMT2A | |
| SCHEMBL4417682 | 0.85 | ACACB (0.49) | ACACBACACAKMT2A | |
| SCHEMBL742140 | 0.85 | ACACB (0.49) | ACACBACACAKMT2A | |
| SCHEMBL741079 | 0.84 | ACACB (0.53) | ACACBACACA | |
| SCHEMBL730518 | 0.84 | ACACB (0.47) | ACACBACACAKMT2A | |
| SCHEMBL731214 | 0.84 | ACACB (0.53) | ACACBACACA | |
| SCHEMBL733394 | 0.84 | ACACB (0.63) | ACACBACACAKMT2A | |
| SCHEMBL731131 | 0.84 | ACACB (0.47) | ACACBACACAKMT2A | |
| SCHEMBL730697 | 0.84 | ACACB (0.47) | ACACBACACAKMT2A | |
| SCHEMBL733228 | 0.83 | ACACB (0.46) | ACACBACACAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | claimed |
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |