Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 13/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730528 | 0.89 | ACACB (0.52) | ACACBACACAKMT2A | |
| SCHEMBL4417682 | 0.87 | ACACB (0.49) | ACACBACACAKMT2AHDAC3HDAC4 | |
| SCHEMBL741079 | 0.86 | ACACB (0.53) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL731214 | 0.86 | ACACB (0.53) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL733394 | 0.86 | ACACB (0.63) | ACACBACACAKMT2A | |
| SCHEMBL742140 | 0.85 | ACACB (0.49) | ACACBACACAKMT2AHDAC3HDAC4 | |
| SCHEMBL15163302 | 0.85 | ACACB (0.52) | ACACBACACAKMT2A | |
| SCHEMBL730821 | 0.85 | ACACB (0.49) | ACACBACACAKMT2A | |
| SCHEMBL4420767 | 0.84 | ACACB (0.48) | ACACBACACAKMT2A | |
| SCHEMBL730697 | 0.84 | ACACB (0.47) | ACACBACACAKMT2AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | claimed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |