SCHEMBL4422049

SCHEMBL4422049

COc1ncc(Cc2cn(CC(=O)N(C)Cc3ccc(-c4ccc(F)cc4F)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1

nearest known ligand 0.86

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 20/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4413978 0.95 PLA2G7 (0.86) PLA2G7
SCHEMBL4419235 0.93 PLA2G7 (0.86) PLA2G7
SCHEMBL4419549 0.93 PLA2G7 (0.86) PLA2G7
SCHEMBL4415307 0.93 PLA2G7 (1.00) PLA2G7
SCHEMBL4415707 0.89 PLA2G7 (1.00) PLA2G7
SCHEMBL4419386 0.89 PLA2G7 (0.88) PLA2G7
SCHEMBL4426870 0.89 PLA2G7 (0.86) PLA2G7
SCHEMBL4416249 0.88 PLA2G7 (1.00) PLA2G7
SCHEMBL4414405 0.87 PLA2G7 (0.86) PLA2G7
SCHEMBL4416276 0.85 PLA2G7 (0.87) PLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1479671-B1 Pyrimidinone compounds SMITHKLINE BEECHAM PLC (GB) 2009-05-27 EP disclosed
US-7115616-B2 Pyrimidinone compounds SMITHKLINE BEECHAM PLC (GB) 2006-10-03 US disclosed