Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984805 | 0.83 | SETDB1 (0.49) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL4019795 | 0.82 | HPGD (0.45) | HPGDALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL11865177 | 0.79 | HPGD (0.42) | HPGDALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL1671880 | 0.79 | KDM4E (0.48) | HPGDALDH1A1KDM4EHTTRCE1 | |
| Hydrochloric Acid SCHEMBL20487425 | 0.78 | HPGD (0.42) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL6156971 | 0.78 | MAPK8 (0.43) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL14941044 | 0.78 | ALDH1A1 (0.43) | HPGDALDH1A1KDM4EHTTRCE1 | |
| SCHEMBL17787939 | 0.77 | ALDH1A1 (0.62) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| Dimethylamine SCHEMBL27639205 | 0.77 | MAPT (0.47) | HPGDALDH1A1KDM4EHTTMAPT | |
| SCHEMBL12851364 | 0.76 | NPC1 (0.79) | NPC1RAB9AALDH1A1HTTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024359-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DECEASE AND/OR SCHIZOPHRENIA | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | claimed |
| WO-2007126362-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DISEASE AND/OR SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | WO | claimed |