SCHEMBL4422722

SCHEMBL4422722

CC(C)(C)CN(Cc1cc(Br)n(S(=O)(=O)c2cccnc2)c1)C(=O)O.Cc1ccc(-c2cc(CN(CC(C)(C)C)C(=O)O)cn2S(=O)(=O)c2cccnc2)c(F)n1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.34
PTGER2 P43116 8/20 0.33
ALDH1A1 P00352 2/20 0.31
HDAC3 O15379 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
GFER P55789 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CNR2 P34972 1/20 0.30
MAPT P10636 1/20 0.30
KDM4E B2RXH2 1/20 0.30
KCNA5 P22460 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2411604 0.95 PTGDR2 (0.35) PTGDR2PTGER2ALDH1A1GAATSHR
SCHEMBL4792901 0.88 PTGDR2 (0.34) PTGDR2PTGER2ALDH1A1HDAC3HDAC1
SCHEMBL1156756 0.87 PTGER2 (0.38) PTGDR2PTGER2ALDH1A1HDAC1TSHR
SCHEMBL1278112 0.86 PTGER2 (0.36) PTGDR2PTGER2ALDH1A1HDAC3HDAC1
SCHEMBL4791526 0.85 NAMPT (0.35) PTGDR2PTGER2ALDH1A1TSHR
Carbamic Acid SCHEMBL4791646 0.85 PTGER2 (0.39) PTGER2ALDH1A1HDAC1TSHRCNR2
SCHEMBL4422716 0.85 PTGDR2 (0.33) PTGDR2GAATSHRGFERSMN1; SMN2
SCHEMBL4791392 0.84 PTGER2 (0.33) PTGDR2PTGER2ALDH1A1KDM4E
SCHEMBL4789906 0.84 MMP9 (0.35) PTGER2GAASMN1; SMN2
SCHEMBL1156219 0.84 PTGDR2 (0.39) PTGDR2PTGER2ALDH1A1GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2114917-A2 PYRROLE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2009-11-11 EP disclosed
WO-2008108380-A2 PYRROLE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-09-12 WO disclosed