⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442336 | 0.67 | — | — | |
| SCHEMBL2850460 | 0.56 | — | — | |
| SCHEMBL11027434 | 0.53 | — | — | |
| SCHEMBL2850462 | 0.53 | — | — | |
| SCHEMBL231188 | 0.52 | — | — | |
| SCHEMBL3482814 | 0.50 | — | — | |
| Water SCHEMBL7962034 | 0.48 | — | — | |
| Hydroxyamine SCHEMBL11177145 | 0.48 | — | — | |
| SCHEMBL2883290 | 0.48 | — | — | |
| SCHEMBL9219479 | 0.47 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884885-B2 | Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis | CHEMGENES CORPORATION (US) | 2018-02-06 | — | — | US | disclosed |
| US-8981076-B2 | Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis | CHEMGENES CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20120065386-A1 | SYNTHESIS OF LABILE BASE PROTECTED - MODIFIED DEOXY & MODIFIED RIBO NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND SUPPORTS AND THEIR USE IN HIGH PURITY OLIGONUCLEOTIDE SYNTHESIS | CHEMGENES CORPORATION | 2012-03-15 | — | — | US | disclosed |
| US-20110015382-A1 | Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis | CHEMGENES CORPORATION (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2010134992-A2 | SYNTHESIS LABILE BASE PROTECTED - MODIFIED DEOXY & MODIFIED RIBO NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND SUPPORTS AND THEIR USE IN HIGH PURITY OLIGONUCLEOTIDE SYNTHESIS | CHEMGENES CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010062404-A2 | N-FMOC NUCLEOSIDES AND PHOSPHORAMIDITES, AND OLIGONUCLEOTIDE SYNTHESIS | CHEMGENES CORPORATION (US) | 2010-06-03 | — | — | WO | disclosed |
| US-7501503-B2 | Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase | MCGILL UNIVERSITY (CA) | 2009-03-10 | — | — | US | disclosed |
| US-6921818-B2 | Purification of oligomers | YALE UNIVERSITY (US) | 2005-07-26 | — | — | US | disclosed |
| US-20040138166-A1 | Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase | MCGILL UNIVERSITY (CA) | 2004-07-15 | — | — | US | disclosed |
| US-20040044190-A1 | Purification of oligomers | SIRNA THERAPEUTICS, INC. | 2004-03-04 | — | — | US | disclosed |
| WO-1997035194-A2 | ENANTIOMERIC SCREENING PROCESS, AND COMPOSITIONS THEREFOR | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1997-09-25 | — | — | WO | disclosed |
| US-5380835-A | Chemically phosphorylating the 5'-hydroxyl terminus of an oligonucleotide | ABBOTT LABORATORIES (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0591302-A4 | — | — | 1994-08-03 | — | — | EP | disclosed |
| EP-0592534-A4 | SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM | ABBOTT LAB (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0592534-A1 | SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM | ABBOTT LABORATORIES (US) | 1994-04-20 | — | — | EP | disclosed |
| EP-0591302-A1 | SUBSTITUTED SILYL ALCOHOLS | ABBOTT LABORATORIES (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1992022557-A1 | SUBSTITUTED SILYL ALCOHOLS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992021689-A1 | SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM | ABBOTT LABORATORIES (US) | 1992-12-10 | — | — | WO | disclosed |
| US-5159095-A | Reagant for phosphorylating oligonucleotides | ABBOTT LABORATORIES (US) | 1992-10-27 | — | — | US | disclosed |
| US-5113005-A | Hydrosilation | ABBOTT LABORATORIES (US) | 1992-05-12 | — | — | US | disclosed |