Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 7/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422170 | 0.88 | LHCGR (0.42) | LHCGRTSHRRIPK2BRAFPDE4A | |
| SCHEMBL4430425 | 0.87 | LHCGR (0.52) | LHCGRTSHRRIPK2BRAFPDE4A | |
| SCHEMBL4418728 | 0.81 | LHCGR (0.57) | LHCGRTSHRRIPK2BRAFPDE4A | |
| SCHEMBL4425814 | 0.81 | LHCGR (0.40) | LHCGRTSHRBRAF | |
| SCHEMBL4423898 | 0.77 | LHCGR (0.55) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL4423875 | 0.77 | LHCGR (0.69) | LHCGRTSHRRIPK2BRAFPDE4A | |
| SCHEMBL4430436 | 0.75 | LHCGR (0.77) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL4428948 | 0.75 | LHCGR (0.52) | LHCGRTSHRRIPK2BRAFPDE4A | |
| SCHEMBL4432167 | 0.74 | LHCGR (0.54) | LHCGRTSHRMAPT | |
| SCHEMBL4313363 | 0.72 | LHCGR (1.00) | LHCGRTSHRRIPK2BRAFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618963-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2009-11-17 | — | — | US | disclosed |
| EP-1886999-A2 | Bicyclic heteroaromatic compound | N.V. Organon (NL) | 2008-02-13 | — | — | EP | disclosed |
| US-20070197527-A1 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-08-23 | — | — | US | disclosed |
| US-7229990-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-06-12 | — | — | US | disclosed |
| US-20030225113-A1 | Bicyclic heteroaromatic compounds | MERCK SHARP & DOHME B.V. (NL) | 2003-12-04 | — | — | US | disclosed |
| EP-1322651-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | Akzo Nobel N.V. (NL) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024703-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | AKZO NOBEL N.V. (NL) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225113-A1 | Bicyclic heteroaromatic compounds | NR5A1, CYP19A1, FSHR | LHCGR 13/4885TSHR 1000/4885RIPK2 4866/4885 |
| US-20070197527-A1 | Bicyclic heteroaromatic compounds | NR5A1, CYP19A1, FSHR | LHCGR 10/4885TSHR 517/4885RIPK2 4878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.