Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | GRK2 | P25098 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848654 | 1.00 | L3MBTL1 (0.63) | L3MBTL1CYP3A4HTR1ATP53CYP1A2 | |
| SCHEMBL4426369 | 1.00 | L3MBTL1 (0.63) | L3MBTL1CYP3A4HTR1ATP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL4434782 | 0.99 | L3MBTL1 (0.62) | L3MBTL1CYP3A4HTR1ATP53CYP1A2 | |
| SCHEMBL20336692 | 0.89 | L3MBTL1 (0.52) | L3MBTL1GRK2 | |
| SCHEMBL18344975 | 0.88 | L3MBTL1 (0.51) | L3MBTL1CYP3A4HTR1ATP53CYP1A2 | |
| SCHEMBL14609009 | 0.87 | L3MBTL1 (0.66) | L3MBTL1CYP3A4HTR1ATP53CYP1A2 | |
| SCHEMBL5329429 | 0.87 | L3MBTL1 (0.66) | L3MBTL1CYP3A4HTR1ATP53CYP1A2 | |
| SCHEMBL20336728 | 0.87 | L3MBTL1 (0.51) | L3MBTL1GRK2 | |
| SCHEMBL20336731 | 0.87 | L3MBTL1 (0.51) | L3MBTL1GRK2 | |
| SCHEMBL20336729 | 0.87 | L3MBTL1 (0.51) | L3MBTL1GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812827-B1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMITOMO CHEMICAL CO (JP) | 2009-09-02 | — | — | EP | claimed |
| US-20060041138-A1 | Process for producing paroxetine hydrochloride hydrate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-02-23 | — | — | US | claimed |
| US-6610851-B1 | 1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-((3,4-methylene dioxyphenyl)oxymethyl)piperidine; reacting 4-(4-fluorophenyl)-3-hydroxymethylpiperidine with di-tert-butyl dicarbonate to form the carbamate; 3,4-methylenedioxyphenol | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-08-26 | — | — | US | claimed |
| US-6476227-B1 | Piperidine derivative and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-11-05 | — | — | US | claimed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | claimed |
| EP-3580207-B1 | DIAZOMETHYLATION REAGENT AND PROCESS FOR USING IT | FUNDACIO PRIVADA INSTITUT CATALA DINVESTIGACIO QUIM ICIQ (ES) | 2020-11-11 | — | — | EP | disclosed |
| EP-0812827-B1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMITOMO CHEMICAL CO (JP) | 2009-09-02 | — | — | EP | disclosed |
| EP-1555263-A4 | PROCESS FOR PRODUCING PAROXETINE HYDROCHLORIDE HYDRATE | SUMITOMO CHEMICAL CO (JP) | 2008-04-16 | — | — | EP | disclosed |
| US-20060041138-A1 | Process for producing paroxetine hydrochloride hydrate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-02-23 | — | — | US | disclosed |
| EP-1555263-A1 | PROCESS FOR PRODUCING PAROXETINE HYDROCHLORIDE HYDRATE | Sumitomo Chemical Company, Limited (JP) | 2005-07-20 | — | — | EP | disclosed |
| US-20040247667-A1 | Novel compound | SMITHKLINE BEECHAM P.L.C. | 2004-12-09 | — | — | US | disclosed |
| US-6815548-B2 | MINTERMEDIATE FOR PHARMACEUTICALS SUCH AS PAROXETINE USEFUL AS ANTIDEPRESSANTS, REPRESENTED BY THE GENERAL FORMULA (I): | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-11-09 | — | — | US | disclosed |
| EP-0970955-B1 | Paroxetine methanesulfonate | SMITHKLINE BEECHAM PLC (GB) | 2000-08-02 | — | — | EP | disclosed |
| EP-1020464-A1 | Paroxetine methansulfonate | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | EP | disclosed |
| EP-1020463-A1 | Paroxetine methanesulfonate | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | EP | disclosed |
| US-6063927-A | CRYSTALLINE PAROXETINE METHANESULFONATE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PARKINSON'S DISEASE | SMITHKLINE BEECHAM PLC (GB) | 2000-05-16 | — | — | US | disclosed |
| EP-0990655-A1 | METHOD FOR DRYING ANHYDROUS PAROXETINE HYDROCHLORIDE | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-04-05 | — | — | EP | disclosed |
| EP-0970955-A1 | Paroxetine methanesulfonate | SMITHKLINE BEECHAM PLC (GB) | 2000-01-12 | — | — | EP | disclosed |
| US-5948914-A | PREPARING 4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE BY OPTICALLY RESOLVING WITH O-CHLOROTARTRANILIC ACID; CHEMICAL INTERMEDIATE FOR DRUGS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | disclosed |