Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.55 |
| ▸ | EDNRB | P24530 | 4/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421491 | 0.93 | EDNRA (0.47) | EDNRAAGTR1EDNRBKCNN3 | |
| SCHEMBL4424916 | 0.87 | EDNRA (0.52) | EDNRAAGTR1EDNRB | |
| SCHEMBL4563627 | 0.87 | EDNRA (0.51) | EDNRAAGTR1EDNRB | |
| SCHEMBL4429112 | 0.85 | EDNRA (0.43) | EDNRAEDNRBKCNN3 | |
| SCHEMBL13574943 | 0.84 | EDNRA (0.56) | EDNRAAGTR1EDNRB | |
| SCHEMBL4563629 | 0.84 | EDNRA (0.49) | EDNRAAGTR1EDNRB | |
| SCHEMBL13574912 | 0.84 | EDNRA (0.41) | EDNRAAGTR1EDNRBKCNN3 | |
| SCHEMBL4426251 | 0.84 | EDNRA (0.40) | EDNRAAGTR1EDNRBKCNN3 | |
| SCHEMBL13574941 | 0.83 | EDNRA (0.55) | EDNRAAGTR1EDNRB | |
| SCHEMBL13574908 | 0.83 | EDNRA (0.56) | EDNRAAGTR1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155448-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009155448-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |