Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.43 |
| ▸ | EDNRB | P24530 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.40 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574911 | 0.92 | EDNRA (0.40) | EDNRAEDNRBMEN1NPC1RAB9A | |
| SCHEMBL13574889 | 0.85 | EDNRA (0.44) | EDNRAEDNRB | |
| SCHEMBL4424315 | 0.85 | EDNRA (0.55) | EDNRAEDNRBKCNN3 | |
| SCHEMBL13574912 | 0.80 | EDNRA (0.41) | EDNRAEDNRBKCNN3 | |
| SCHEMBL4421491 | 0.78 | EDNRA (0.47) | EDNRAEDNRBKCNN1KCNN2KCNN3 | |
| SCHEMBL7441417 | 0.74 | MEN1 (0.49) | MEN1NPC1RAB9AKMT2AKCNN1 | |
| SCHEMBL7557151 | 0.74 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL6767700 | 0.74 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL4287019 | 0.74 | EDNRA (0.44) | EDNRAEDNRB | |
| SCHEMBL4424916 | 0.73 | EDNRA (0.52) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155448-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | claimed |
| WO-2009155448-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |