Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29624123 | 0.77 | KMT2A (0.72) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL9365789 | 0.77 | KMT2A (0.72) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL27890245 | 0.68 | MEN1 (1.00) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8342841 | 0.66 | KMT2A (0.65) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8342494 | 0.65 | LMNA (0.75) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8346200 | 0.65 | MEN1 (0.52) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL9369302 | 0.65 | LMNA (0.78) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL28000955 | 0.64 | MEN1 (0.35) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8342323 | 0.64 | LMNA (0.72) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL9365729 | 0.64 | LMNA (0.72) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553967-B2 | 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH (US) | 2009-06-30 | — | — | US | claimed |
| WO-2005090309-A1 | 1,2-DIHYDROQUINOLINE DERIVATIVES AND METHOD FOR USING THE SAME TO TREAT HIV INFECTION | WYETH (US) | 2005-09-29 | — | — | WO | claimed |
| US-20050203129-A1 | 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH | 2005-09-15 | — | — | US | claimed |
| US-7553967-B2 | 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| WO-2005090309-A1 | 1,2-DIHYDROQUINOLINE DERIVATIVES AND METHOD FOR USING THE SAME TO TREAT HIV INFECTION | WYETH (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20050203129-A1 | 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203129-A1 | 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | CBR3, CBR1, NR1H3 | MEN1 3500/4885KMT2A 1636/4885ALDH1A1 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.