SCHEMBL4424907

SCHEMBL4424907

C=Cc1nc(N)c2nc[nH]c2n1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.31
GDA Q9Y2T3 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4412909 0.76
2,6-Diaminopurine SCHEMBL29444619 0.75 GDA (0.48) PDPK1GDA
2,6-Diaminopurine SCHEMBL24052 0.75 GDA (0.48) PDPK1GDA
SCHEMBL325148 0.75 CDK1 (0.33)
SCHEMBL669639 0.73
2,6-Diaminopurine SCHEMBL6423146 0.73 GDA (0.47) PDPK1GDA
2,6-Diaminopurine SCHEMBL8757968 0.73 GDA (0.47) PDPK1GDA
SCHEMBL8506347 0.72 GDA (0.34) GDA
SCHEMBL8523000 0.72 INSR (0.39)
SCHEMBL490902 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3394118-A1 DETERGENT ADDITIVE FOR FUEL, AND COPOLYMERS USABLE IN SAID APPLICATION Total Marketing Services (FR) 2018-10-31 EP claimed
WO-2017109369-A1 DETERGENT ADDITIVE FOR FUEL, AND COPOLYMERS USABLE IN SAID APPLICATION TOTAL MARKETING SERVICES (FR) 2017-06-29 WO claimed
EP-3512860-B1 NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT LCB PHARMA INC (CA) 2020-11-25 EP disclosed
EP-3394118-A1 DETERGENT ADDITIVE FOR FUEL, AND COPOLYMERS USABLE IN SAID APPLICATION Total Marketing Services (FR) 2018-10-31 EP disclosed
WO-2017109369-A1 DETERGENT ADDITIVE FOR FUEL, AND COPOLYMERS USABLE IN SAID APPLICATION TOTAL MARKETING SERVICES (FR) 2017-06-29 WO disclosed
US-9156874-B2 Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs NANJING MOLECULAR RESEARCH, INC. (CN) 2015-10-13 US disclosed
US-9095599-B2 O-(substituted benzyl) phosphoramidate compounds and therapeutic use NANJING MOLECULAR RESEARCH, INC. (CN) 2015-08-04 US disclosed
US-20140038916-A1 O-(SUBSTITUTED BENZYL) PHOSPHORAMIDATE COMPOUNDS AND THERAPEUTIC USE NANJING MOLECULAR RESEARCH, INC. (CN) 2014-02-06 US disclosed
WO-2013187978-A1 DOUBLE-LIVER-TARGETING PHOSPHORAMIDATE AND PHOSPHONOAMIDATE PRODRUGS NANJING MOLECULAR RESEARCH, INC. (CN) 2013-12-19 WO disclosed
US-20130210757-A1 DOUBLE-LIVER-TARGETING PHOSPHORAMIDATE AND PHOSPHONOAMIDATE PRODRUGS NANJING MOLECULAR RESEARCH, INC. (CN) 2013-08-15 US disclosed
WO-2012094248-A1 O-(SUBSTITUTED BENZYL) PHOSPHORAMIDATE COMPOUNDS AND THERAPEUTIC USE NANJING MOLECULAR RESEARCH, INC. (CN) 2012-07-12 WO disclosed
US-7585851-B2 3′-prodrugs of 2′-deoxy-β-L-nucleosides IDENIX PHARMACEUTICALS, INC. (US) 2009-09-08 US disclosed
US-6214187-B1 ANALYZING NUCLEIC ACID SEQUENCES MOSAIC TECHNOLOGIES 2001-04-10 US disclosed
EP-1086248-A1 DENATURING GRADIENT AFFINITY ELECTROPHORESIS AND METHODS OF USE THEREOF MOSAIC TECHNOLOGIES, INC. (US) 2001-03-28 EP disclosed
EP-1068518-A2 PURIFICATION AND DETECTION PROCESSES USING REVERSIBLE AFFINITY ELECTROPHORESIS Exact Sciences Corporation (US) 2001-01-17 EP disclosed
WO-1999066078-A1 DENATURING GRADIENT AFFINITY ELECTROPHORESIS AND METHODS OF USE THEREOF MOSAIC TECHNOLOGIES (US) 1999-12-23 WO disclosed
WO-1999045374-A2 PURIFICATION AND DETECTION PROCESSES USING REVERSIBLE AFFINITY ELECTROPHORESIS MOSAIC TECHNOLOGIES (US) 1999-09-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140038916-A1 O-(SUBSTITUTED BENZYL) PHOSPHORAMIDATE COMPOUNDS AND THERAPEUTIC USE PNP, PAICS, TYMP PDPK1 880/4885GDA 92/4885
US-20130210757-A1 DOUBLE-LIVER-TARGETING PHOSPHORAMIDATE AND PHOSPHONOAMIDATE PRODRUGS PNP, PAICS, NTPCR PDPK1 780/4885GDA 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.