SCHEMBL4424974

SCHEMBL4424974

Cc1nc(F)c(CO)c(C=O)c1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
HPGD P15428 1/20 0.46
KMT2A Q03164 1/20 0.46
AOX1 Q06278 1/20 0.46
TRIM24 O15164 1/20 0.45
TRIM33 Q9UPN9 1/20 0.45
ERN1 O75460 1/20 0.41
P2RX3 P56373 3/20 0.37
IGF1R P08069 1/20 0.37
SRC P12931 1/20 0.37
AXL P30530 1/20 0.37
PTK2 Q05397 1/20 0.37
AURKB Q96GD4 1/20 0.37
ALK Q9UM73 1/20 0.37
YWHAG P61981 1/20 0.34
YWHAZ P63104 1/20 0.34
P2RX7 Q99572 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2692703 0.84 KDM4E (0.50) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL29616270 0.82 KDM4E (0.49) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL4432210 0.77 KDM4E (0.42) KDM4EALDH1A1LMNAHPGD
SCHEMBL10787968 0.76 KDM4E (0.43) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL28432395 0.76 KDM4E (0.43) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL14237027 0.72 ERN1 (0.55) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL6854296 0.72 P2RX2 (0.43) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL1527081 0.68 IGF1R (0.65) KDM4EMEN1ALDH1A1LMNAHPGD
SCHEMBL18218329 0.66 ERBB2 (0.41) KDM4EMEN1ALDH1A1LMNAHPGD
Pyridoxal SCHEMBL2343580 0.65 KDM4E (0.85) KDM4EMEN1ALDH1A1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090191131-A1 USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS FOSSHEIM SIGRID LISE 2009-07-30 US disclosed
US-20050136002-A1 Use of particulate contrast agents in diagnostic imaging for studying physiological paramaters GE HEALTHCARE AS (NO) 2005-06-23 US disclosed
EP-1069888-B1 USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMETERS AMERSHAM HEALTH AS (NO) 2004-09-22 EP disclosed
EP-1069888-A1 USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMETERS NYCOMED IMAGING AS (NO) 2001-01-24 EP disclosed
WO-1999052505-A1 USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMETERS NYCOMED IMAGING A.S. (NO) 1999-10-21 WO disclosed