Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 0.85 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.85 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.85 |
| ▸ | SHBG | P04278 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | PGR | P06401 | 2/20 | 0.85 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.85 |
| ▸ | MAPT | P10636 | 1/20 | 0.85 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 4/20 | 0.83 |
| ▸ | TSHR | P16473 | 3/20 | 0.83 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.83 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cortisone Acetate SCHEMBL19463056 | 0.93 | HIF1A (0.81) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Cortisone Acetate SCHEMBL19463054 | 0.93 | HIF1A (0.81) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL6932400 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL10261067 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL10292969 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL24900238 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL1688689 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL5699764 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL1560948 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 | |
| Hydrocortisone SCHEMBL143923 | 0.92 | HIF1A (1.00) | HIF1AHSD17B10SERPINA6NR3C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230141499-A1 | CARDIOSPHERE-DERIVED CELL (CDC) THERAPY FOR THE TREATMENT OF VIRAL INFECTIONS | CEDARS-SINAI MEDICAL CENTER | 2023-05-11 | — | — | US | claimed |
| WO-2021188899-A1 | CARDIOSPHERE-DERIVED CELL (CDC) THERAPY FOR THE TREATMENT OF VIRAL INFECTIONS | CEDARS-SINAI MEDICAL CENTER (US) | 2021-09-23 | — | — | WO | claimed |
| EP-1365766-B1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF PHIMOSIS USING TOPICAL CORTICOSTEROID | APSEN FARMACEUTICA S A (BR) | 2006-06-21 | — | — | EP | claimed |
| US-20040067922-A1 | Pharmaceutical composition for treatment of phimosis using topical corticosteroid | APSEN FARMACEUTICA S.A. (BR) | 2004-04-08 | — | — | US | claimed |
| EP-1365766-A2 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF PHIMOSIS USING TOPICAL CORTICOSTEROID | Apsen Farmaceutica S.A. (BR) | 2003-12-03 | — | — | EP | claimed |
| WO-2002053137-A2 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF PHIMOSIS USING TOPICAL CORTICOSTEROID | APSEN FARMACÊUTICA S.A. (BR) | 2002-07-11 | — | — | WO | claimed |
| WO-2023240222-A2 | IMMUNE TOLERANCE INDUCTION TO VIRAL CAPSIDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023178338-A2 | METHODS AND COMPOSITIONS FOR TREATING TMEM43 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023178339-A2 | METHODS AND COMPOSITIONS FOR TREATING TNNT2 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023178337-A2 | METHODS AND COMPOSITIONS FOR TREATING RBM20 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023108159-A1 | METHODS AND COMPOSITIONS FOR TREATING BAG-3 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023108157-A1 | METHODS AND COMPOSITIONS FOR TREATING MYBPC3 RELATED HYPERTROPHIC CARDIOMYOPATHY WITH A VIRAL VECTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023108130-A2 | COMPOSITIONS COMPRISING KOZAK SEQUENCES SELECTED FOR ENHANCED EXPRESSION | AAVANTIBIO, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| US-5326761-A | Suspension; sustained release | MERCK SHARP & DOHME-CHIBRET (FR) | 1994-07-05 | — | — | US | disclosed |
| EP-0437368-B1 | Fluid ophthalmic composition based on lipid microparticles containing at least one active principle | MERCK SHARP & DOHME (FR) | 1994-03-02 | — | — | EP | disclosed |
| EP-0454773-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | Bundgaard, Hans (DK) | 1991-11-06 | — | — | EP | disclosed |
| EP-0437368-A1 | Fluid ophthalmic composition based on lipid microparticles containing at least one active principle | LABORATOIRES MERCK, SHARP & DOHME-CHIBRET (FR) | 1991-07-17 | — | — | EP | disclosed |
| WO-1990008128-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | BUNDGAARD HANS (DK) | 1990-07-26 | — | — | WO | disclosed |
| US-4668455-A | THERMOPLASTIC, MELTS, EXTRUSION, RODS, PELLETIZATION | NORDTEND A/S (NO) | 1987-05-26 | — | — | US | disclosed |
| US-4657759-A | SMELL-REPELLENT HUMAN STEROID IN A THERMOPLASTIC MATRIX; SUSTAINED RELEASE | NORDTEND A/S (NO) | 1987-04-14 | — | — | US | disclosed |