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Cortisone Acetate

Cortisone Acetate

SCHEMBL19463054

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@@]21C.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Cortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 4/20 0.79
▸ HIF1A Q16665 9/20 0.81
▸ SERPINA6 P08185 3/20 0.81
▸ AR P10275 2/20 0.81
▸ PGR P06401 2/20 0.81
▸ LMNA P02545 2/20 0.81
▸ CHRM1 P11229 1/20 0.81
▸ FNTA P49354 4/20 0.79
▸ FNTB P49356 4/20 0.79
▸ TSHR P16473 3/20 0.79
▸ KMT2A Q03164 2/20 0.79
▸ MEN1 O00255 1/20 0.79
▸ BLM P54132 1/20 0.79
▸ HSD17B10 Q99714 5/20 0.73
▸ SMN1; SMN2 Q16637 4/20 0.73
▸ CYP3A4 P08684 3/20 0.73
▸ CYP2C19 P33261 2/20 0.73
▸ SHBG P04278 2/20 0.73
▸ NFKB1 P19838 2/20 0.73
▸ MAPT P10636 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cortisone Acetate SCHEMBL19463056 1.00 HIF1A (0.81) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL365254 0.93 HIF1A (0.93) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL7520412 0.93 HIF1A (0.93) HIF1ASERPINA6ARPGRLMNA
Cortisone SCHEMBL442505 0.93 HIF1A (0.85) HIF1ASERPINA6ARPGRLMNA
Cortisone Acetate SCHEMBL17966400 0.92 HIF1A (0.74) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL4940901 0.90 HIF1A (1.00) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL7419 0.90 HIF1A (1.00) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL25599370 0.90 HIF1A (1.00) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL13026148 0.90 HIF1A (1.00) HIF1ASERPINA6ARPGRLMNA
Hydrocortisone Acetate SCHEMBL2452043 0.90 HIF1A (1.00) HIF1ASERPINA6ARPGRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3442997-A2 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION Indiana University Research & Technology Corporation (US) 2019-02-20 — — EP disclosed
WO-2017210242-A1 INSULIN-NUCLEAR HORMONE CONJUGATES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-12-07 — — WO disclosed
WO-2017180988-A2 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-10-19 — — WO disclosed