Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.56 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.54 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425184 | 1.00 | MAOB (0.58) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL4429913 | 0.85 | MAOB (0.55) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL4429916 | 0.85 | MAOB (0.55) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL3289301 | 0.81 | SCN9A (0.77) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL1069620 | 0.81 | SCN9A (0.77) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL22874551 | 0.79 | MAOB (0.59) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL4422092 | 0.79 | MAOB (0.63) | MAOBSCN9APARP15PARP10PARP14 | |
| SCHEMBL4425537 | 0.78 | MAOB (0.60) | MAOBSCN9APARP10MEN1KMT2A | |
| SCHEMBL4425539 | 0.78 | MAOB (0.60) | MAOBSCN9APARP10MEN1KMT2A | |
| SCHEMBL28884365 | 0.77 | POLB (0.58) | SCN9AGAAPOLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | disclosed |
| US-7253318-B2 | Benzyloxy derivatives as MAOB inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| EP-1761480-A2 | NEW MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000324-A2 | NEW MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-05 | — | — | WO | disclosed |
| US-20050288367-A1 | Benzyloxy derivatives as MAOB inhibitors | HOFFMAN-LA ROCHE INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288367-A1 | Benzyloxy derivatives as MAOB inhibitors | MAOB, MAOA, COMT | MAOB 1/4885SCN9A 1816/4885PARP15 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.