Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 19/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428309 | 0.90 | POLB (0.45) | CLK1CLK2CLK4DYRK1A | |
| SCHEMBL445756 | 0.80 | CLK1 (0.61) | CLK1PPARACLK2CLK4DYRK1A | |
| SCHEMBL4554027 | 0.78 | KDM4E (0.60) | — | |
| SCHEMBL4249835 | 0.77 | CLK1 (0.58) | CLK1PPARACLK2CLK4DYRK1A | |
| SCHEMBL5807938 | 0.77 | MEN1 (0.48) | CLK1 | |
| SCHEMBL5794058 | 0.76 | SLC9A1 (0.45) | DYRK1A | |
| SCHEMBL4432409 | 0.73 | KMT2A (0.55) | — | |
| SCHEMBL7340422 | 0.73 | CLK1 (0.67) | CLK1CLK2CLK4DYRK1A | |
| SCHEMBL12116990 | 0.72 | CHEK1 (0.50) | — | |
| SCHEMBL443592 | 0.71 | HDAC1 (0.54) | CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099442-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008082856-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |