Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554027 | 0.82 | KDM4E (0.60) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL445848 | 0.81 | HDAC3 (0.62) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL4253730 | 0.79 | HDAC3 (0.59) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL4432409 | 0.77 | KMT2A (0.55) | POLBRAB9ANPC1HDAC1HDAC2 | |
| SCHEMBL24448134 | 0.74 | POLB (0.70) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL26179123 | 0.73 | RAB9A (0.70) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL24020783 | 0.73 | HDAC3 (0.74) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL24019729 | 0.73 | RAB9A (0.69) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL24447653 | 0.72 | FLT3 (0.66) | POLBRAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL29394458 | 0.72 | FLT3 (0.66) | POLBRAB9ANPC1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099442-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008082856-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |