Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 14/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368998 | 1.00 | HTT (0.43) | HTTCCR3DRD3DRD2HTR2A | |
| SCHEMBL14369049 | 0.89 | CCR3 (0.44) | HTTCCR3DRD2HTR2AHTR2C | |
| SCHEMBL5664036 | 0.89 | CCR3 (0.44) | CCR3DRD2HTR2ACYP2D6SLC6A2 | |
| SCHEMBL4428998 | 0.89 | CCR3 (0.44) | CCR3DRD2HTR2ACYP2D6SLC6A2 | |
| SCHEMBL4428996 | 0.89 | CCR3 (0.44) | CCR3DRD2HTR2ACYP2D6SLC6A2 | |
| SCHEMBL14368995 | 0.89 | CCR3 (0.40) | CCR3CYP2D6 | |
| SCHEMBL14368994 | 0.88 | CCR3 (0.43) | HTTCCR3DRD3DRD2HTR2A | |
| SCHEMBL4426204 | 0.88 | CCR3 (0.43) | HTTCCR3DRD3DRD2HTR2A | |
| SCHEMBL4566657 | 0.87 | CCR3 (0.44) | HTTCCR3DRD2HTR2AHTR2C | |
| SCHEMBL14369059 | 0.87 | CCR3 (0.44) | HTTCCR3DRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |
| EP-2024359-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DECEASE AND/OR SCHIZOPHRENIA | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007126362-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DISEASE AND/OR SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | WO | disclosed |