Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Zonisamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CA1 | P00915 | 2/20 | 1.00 |
| ▸ | CA2 | P00918 | 2/20 | 1.00 |
| ▸ | CA5A | P35218 | 2/20 | 1.00 |
| ▸ | CA9 | Q16790 | 2/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 1.00 |
| ▸ | CA3 | P07451 | 1/20 | 1.00 |
| ▸ | CA4 | P22748 | 1/20 | 1.00 |
| ▸ | CA6 | P23280 | 1/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 1.00 |
| ▸ | CA7 | P43166 | 1/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zonisamide SCHEMBL29358822 | 1.00 | LMNA (1.00) | LMNACA1CA2CA5ACA9 | |
| Zonisamide SCHEMBL35458 | 1.00 | LMNA (1.00) | LMNACA1CA2CA5ACA9 | |
| Zonisamide SCHEMBL1816247 | 1.00 | LMNA (1.00) | LMNACA1CA2CA5ACA9 | |
| Zonisamide SCHEMBL688524 | 0.98 | LMNA (0.97) | LMNACA1CA2CA5ACA9 | |
| Zonisamide SCHEMBL689298 | 0.98 | LMNA (0.97) | LMNACA1CA2CA5ACA9 | |
| Zonisamide SCHEMBL1321446 | 0.98 | LMNA (0.97) | LMNACA1CA2CA5ACA9 | |
| Zonisamide SCHEMBL28757455 | 0.95 | LMNA (0.90) | LMNACA1CA2CA5ACA9 | |
| SCHEMBL3143718 | 0.84 | LMNA (0.73) | LMNACA1CA2CA5ACA9 | |
| SCHEMBL3239117 | 0.84 | LMNA (0.73) | LMNACA1CA2CA5ACA9 | |
| SCHEMBL1272549 | 0.84 | LMNA (0.73) | LMNACA1CA2CA5ACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089005-A2 | LAYERED PHARMACEUTICAL FORMULATIONS COMPRISING AN INTERMEDIATE RAPIDLY DISSOLVING LAYER | Orexigen Therapeutics, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008060963-A2 | LAYERED PHARMACEUTICAL FORMULATIONS COMPRISING AN INTERMEDIATE RAPIDLY DISSOLVING LAYER | OREXIGEN THERAPEUTICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |