Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.43 |
| ▸ | MTTP | P55157 | 2/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431836 | 0.89 | P2RX7 (0.44) | P2RX7GPR88EP300CCR2 | |
| SCHEMBL4432328 | 0.89 | P2RX7 (0.44) | P2RX7GPR88EP300CCR2 | |
| SCHEMBL4441892 | 0.88 | P2RX7 (0.46) | P2RX7EP300CCR2 | |
| SCHEMBL4432326 | 0.87 | P2RX7 (0.45) | P2RX7EP300CCR2 | |
| SCHEMBL4436024 | 0.87 | P2RX7 (0.44) | P2RX7EP300CCR2 | |
| SCHEMBL4440623 | 0.86 | P2RX7 (0.45) | P2RX7GPR88EP300CCR2 | |
| SCHEMBL4430509 | 0.84 | P2RX7 (0.44) | P2RX7EP300 | |
| SCHEMBL4429659 | 0.84 | P2RX7 (0.44) | P2RX7EP300 | |
| SCHEMBL4432823 | 0.84 | P2RX7 (0.44) | P2RX7EP300 | |
| SCHEMBL4432393 | 0.84 | P2RX7 (0.44) | P2RX7EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |