Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310783 | 0.76 | HDAC6 (0.41) | GRM5HDAC6ROCK2ROCK1 | |
| SCHEMBL19029807 | 0.76 | LRRK2 (0.33) | — | |
| SCHEMBL4967402 | 0.74 | USP2 (0.37) | GRM5 | |
| SCHEMBL26089064 | 0.73 | HDAC6 (0.44) | HDAC6ROCK2ROCK1 | |
| SCHEMBL30703833 | 0.72 | HDAC6 (0.41) | GRM5HDAC6ROCK2ROCK1 | |
| SCHEMBL30755929 | 0.68 | HDAC6 (0.32) | HDAC6ROCK2ROCK1 | |
| SCHEMBL173333 | 0.68 | HRH4 (0.36) | ROCK2ROCK1 | |
| SCHEMBL24424423 | 0.68 | TDP1 (0.32) | ROCK2ROCK1 | |
| SCHEMBL22421143 | 0.68 | ROCK2 (0.32) | ROCK2ROCK1 | |
| SCHEMBL24423442 | 0.68 | CYP2C19 (0.35) | GRM5ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132193-B1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2132193-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | Boehringer Ingelheim International GmbH (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116881-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-02 | — | — | WO | disclosed |