SCHEMBL4428266

SCHEMBL4428266

CCN(Cc1ccccc1)c1ccc(C(C)c2ccc(C(C)c3ccc(N(CC)Cc4ccccc4)cc3)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.70
CNR2 P34972 11/20 0.59
NR1H2 P55055 1/20 0.54
NR1H3 Q13133 1/20 0.54
CNR1 P21554 3/20 0.53
CYP2C19 P33261 1/20 0.53
KDM4E B2RXH2 3/20 0.49
ALDH1A1 P00352 3/20 0.49
LMNA P02545 3/20 0.49
MAPT P10636 3/20 0.49
HPGD P15428 2/20 0.49
MAPK1 P28482 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
MITF O75030 1/20 0.49
RAD52 P43351 1/20 0.49
KMT2A Q03164 1/20 0.49
ALOX12 P18054 1/20 0.48
HTT P42858 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.45
GRM2 Q14416 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14308405 0.97 TSHR (0.66) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL12145190 0.94 TSHR (0.62) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL13539136 0.94 CYP2C19 (0.65) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL10779746 0.91 CYP2C19 (0.63) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL5949383 0.91 CYP2C19 (0.63) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL14318831 0.91 CYP2C19 (0.61) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL12145611 0.86 TSHR (0.53) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL5011841 0.86 TSHR (0.70) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL3905890 0.86 TSHR (0.70) TSHRCNR2NR1H2NR1H3CNR1
SCHEMBL3890200 0.85 CNR2 (0.52) TSHRCNR2NR1H2NR1H3CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8178266-B2 Electrophotographic photoreceptor, image forming apparatus using the electrophotographic photoreceptor, and method of producing electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2012-05-15 US disclosed
US-8173343-B2 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH COMPANY, LTD. (JP) 2012-05-08 US disclosed
US-7729634-B2 Image forming apparatus, image forming method, and process cartridge RICOH COMPANY, LTD. (JP) 2010-06-01 US disclosed
US-20100015538-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS USING THE SAME, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2010-01-21 US disclosed
US-20090324281-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS USING THE ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTORECEPTOR RICOH COMPANY, LTD. (JP) 2009-12-31 US disclosed
US-20080219694-A1 IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2008-09-11 US disclosed
US-20080113285-A1 IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2008-05-15 US disclosed
US-20080112742-A1 IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2008-05-15 US disclosed