Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298574 | 0.95 | CDC7 (0.33) | CDC7SLC6A2CYP19A1BRD4KMT2A | |
| SCHEMBL4430982 | 0.87 | ROCK1 (0.32) | BRD4 | |
| SCHEMBL4431375 | 0.86 | CDC7 (0.43) | CDC7SLC6A2CYP19A1MAPTALDH1A1 | |
| SCHEMBL3299206 | 0.83 | CDC7 (0.44) | CDC7SLC6A2KMT2AMEN1 | |
| SCHEMBL3295555 | 0.81 | DGAT1 (0.32) | BRD4 | |
| SCHEMBL13391040 | 0.80 | CDC7 (0.35) | CDC7SLC6A2CYP19A1BRD4KMT2A | |
| SCHEMBL10318655 | 0.78 | F2 (0.36) | BRD4 | |
| SCHEMBL4438782 | 0.78 | ROCK1 (0.38) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL13409472 | 0.77 | — | — | |
| SCHEMBL3300901 | 0.73 | MAPT (0.55) | KMT2AMEN1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125594-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |